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Macrophage-hitchhiking supramolecular aggregates of CuS nanoparticles for enhanced tumor deposition and photothermal remedy

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On this design, small CuS nanoparticles (NPs) have been intracellularly self-assembled into giant supramolecular aggregates by way of host–visitor interactions between sequentially internalized β-cyclodextrin-capped CuS NPs and ferrocene-capped CuS NPs inside macrophages, thus the efflux of CuS NPs was considerably inhibited in the course of the macrophage-hitchhiking supply. Biodistribution research in mice confirmed the dramatically enhanced deposition of CuS NPs within the tumor tissue of mice injected with macrophages carrying intracellular CuS aggregates, compared to that of mice handled with macrophages carrying CuS NPs. In response to the inflammatory tumor microenvironment, the oxidation of ferrocene would dissociate the β-cyclodextrin–ferrocene host–visitor pair, driving disassembly of the CuS aggregates and launch of small CuS NPs for deep tissue penetration and enhanced photothermal remedy. This exactly managed intracellular self-assembly and disassembly of the nanomedicine inside macrophages supplies a novel cell-hitchhiking supply technique that not solely minimizes untimely leakage of the nanomedicine but additionally enormously improves the supply effectivity and tumor penetration for protected, efficient tumor remedy.

Graphical abstract: Macrophage-hitchhiking supramolecular aggregates of CuS nanoparticles for enhanced tumor deposition and photothermal therapy

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